STUDY THE PROTONATION POINT FOR NITROGLYCER-INE AND EFFECT OF NITROGLYCERINE ON ISOELECTRIC POINT OF VARIOUS AMINO ACIDS

Abstract

Nitroglycerin, which is also commonly referred to as GTN, is an extremely powerful secondary explosive. It is particularly more dangerous than other traditional explosions because it is extremely unstable. Being unstable means that any unnecessary movement can cause the substance to detonate, making unstable substances extremely hazardous and dangerous to work with or around. Nitroglycerin ointment (Nitro-Bid) is used to prevent episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Nitroglycerin ointment can only be used to prevent attacks of angina; it cannot be used to treat an attack of angina once it has begun. Nitroglycerin ointment (Rectiv) is used in adults to treat pain from anal fissures (a split or tear in the tissue near the rectal area). Nitroglycerin is in a class of medications called vasodilators. Nitroglycerin ointment prevents angina by relaxing the blood vessels so that the heart does not need to work as hard and therefore does not need as much oxygen. Each amino acid has a pH at which almost all of the molecules are present in the zwitterionic form (0 net charge). At a pH below the isoelectric point, the cation concentration increases (net (+) charge: protonation occurs, excess H⁺).At a pH above the isoelectric point, the anion concentration increases (net (–) charge: deprotonation occurs, excess OH^–). In the present study we proposed to observe protation for nitroglycerine and effect of nitroglycerine on isoelectric point of amino acid. This Study is found to provide interesting and significant data, which possibly may have correlation with significant protonation point by addition of various amount nitroglycerine on these amino acids.