ENHANCED TRANSDERMAL DELIVERY OF DILTIAZEM HYDROCHLORIDE VIA REVERSE MICELLAR TRANSFORMATION TYPE LIQUID CRYSTALLINE GEL
Keywords:
Reverse micelle, liquid crystals, transdermal drug delivery, in vitro evaluationAbstract
Reverse micelle transformation based liquid crystalline (TLC) transdermal gel of diltiazem hydrochloride was prepared and evaluated. The gel was prepared using lecithin and isopropyl myristate and evaluated for anisotropy, vesicular size and size distribution, drug entrapment efficiency, viscosity and in vitro drug release study. Three formulation of TLC gel were prepared which differed in the ratio of soya lecithin and isopropyl myristate. Formulation TLC1 found to have better property in term of viscosity and in vitro drug release study. Handling of transdermal gel is important aspect which was good for TLC1 and also shown controlled drug delivery of diltiazem hydrochloride.
Downloads
References
Stevenson CL, Bennett DB, Ballesteros DL. Pharmaceutical liquid crystals: the relevance of partially ordered systems. J. Pharm. Sci. 2005; 94: 1861-79.
Mueller-Goymann CC. Liquid crystals in drug delivery. In: Swarbrick J, Boylan JC. editors. Encyclopedia of pharmaceutical technology, New York and Basel: Marcel Dekker Inc., 834-53 (2002).
Mueller-Goymann CC, Frank SG. Interaction of lidocaine and lidocaine hydrochloride with liquid crystal structure of topical preparation. Int. J. Pharm. 1986; 29: 147-59.
Tiemessen HLGM, Bodde HE, Mourik C, Van Junginger HE. In vitro drug release from liquid crystalline creams; cream structure dependence. Progr. Colloid Polym. Sci. 1988; 77: 131–135.
Tyle P. Liquid Crystals and Their Applications in Drug Delivery. In: Rosoff, M. (Ed.), Controlled Release of Drugs: Polymers and Aggregate Systems, VCH Publishers, 125–162 (1989).
Davis SS. Viscoelastic properties of pharmaceutical semisolids I: ointment bases. J. Pharm. Sci. 1969; 58: 412–417.
Buckley MT, Grant SM, Goa KL, McTavish D, Sorkin EM. Diltiazem. A reappraisal of its pharmacological properties and therapeutic use. Drugs. 1990; 39: 757-806.
Pichard L, Gillet G, Fabre I, et al. Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem. Drug Metab Dispos. 1990; 18: 711-719.
Hermann P, Rodger SD, Remones G, Thenot JP, London DR, Morselli PL. Pharmacokinetics of diltiazem after intravenous and oral administration. Eur. J. Clin. Pharmacol. 1983; 24: 349-352.
Smith MS, Verghese CP, Shand DG, Pritchett ELC. Pharmacokinetic and pharmacodynamic effects of diltiazem. Am. J. Cardiol. 1983; 51: 1369-1374.
Mueller-Goymann CC, Hamann HJ. Sustained release from reverse micellar solutions by phase transformation into lamellar liquid crystals. J Control Release 1993; 23: 165-174.
Makai M, Csanyi E, Nemeth Zs, Palinkas J, Eros I. Structure and drug release of lamellar liquid crystals containing glycerol. Int. J. Pharm. 2003; 256: 95-107.
Omray LK, Kohli S, Khopade AJ, Patil S, Gajbhiye Asmita, Agrawal GP. Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol. Indian J. Pharm. Sci. 2008; 70: 578-584.
Kumar R, Katare OP. Lecithin organogels as a potential phospholipid structured system for topical drug delivery: a review. AAPS. PharmSciTech. 2005; 6: E298-E310.
Guy RH, Hadgrft J. Physicochemical aspects of percutaneous penetration and its enhancement. Pharm. Res. 1988; 5: 753-758.
Chien YW, Keshary PR, Hung YC, Sarpotdar PP. Comparative controlled skin permeation of nitroglycerin from marketed transdermal delivery systems. J. Pharm. Sci. 1983; 72: 968-970.
Indian Pharmacopoeia. 3rd ed. New Delhi: Published by the Controller of Publications. 1985. 425.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
