Comparative Biochemical Implications of administrations of extracts of Scoparia dulcis and Loranthus begwensis in Normal and Alloxan-induced Diabetic Rats.
Keywords:
Alloxan, Diabetic States, Loranthus begwensis, Scoparia dulcis, Transaminases, UreaAbstract
The comparative effects of aqueous extracts of Scoparia dulcis and African Mistletoe (Loranthus begwensis) from two host plants (Cocoa and almond) on biochemical parameters (that are indicators of disorders associated with the diabetic states) in normal and alloxan induced diabetic rat were studied. The rats were treated orally with the extracts at a dose of 500mg/kg/day for six days. Induction of diabetes with alloxan resulted in a significant increase (P<0.05) in plasma creatinine and urea. A significant reduction (P<0.05) in plasma creatinine, urea and ALP resulted from the treatment with the three extracts, as well as a non significant (P > 0.05) reduction in total bilirubin. AST and ALT were not significantly (P > 0.05) increased by the plant extracts. The plant extracts appeared not to be toxic to the tissues at the dose they were administered. Mistletoe and Scoparia dulcis extract appeared to possibly ameliorate the complications associated with diabetes mellitus, offering the possibility of their clinical use in its management. Thus, Scoparia dulcis and African mistletoe (Loranthus begwensis) from the two host plants (cocoa and almond) are relatively safe and effective in the management of disorders associated with the diabetic state.
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Aghagboren C. Osaro, Uadia O. Patrick and Omage Kingsley. (2014). Comparative Hypoglyceamic Properties of Scoparia dulcis and Loranthus begwensis as well as their effects on some Biochemical Parameters in Normal and Alloxan-Induced Diabetic Rats. Journal of Pharmaceutical Biology. 4(1): 31 – 40.
Bansal, R., Ahmad, N. and Kidwai, J.R.(1980). Alloxan-glucose interaction: effect of incorporation of 14C-leucine into pancreatic islets of rats. Acta Diabetol Lat 17: 135-143.
Bartels, H. and Bohmer, M. (1972). Kinetic determination of creatinine concentration. Clin. Chem. Acta., 37-193.
Boquist, L., Nelson, L. and Lorentzon, R.(1983). Uptake of labeled alloxan in mouse organs and mitochondria in vivo and in vitro. Endocrinology 113: 943-948.
Boylan, J.M., Brautigan, D.L., Madden, J., Raven, T., Ellis, L. and Gruppuso, P.A. (1992). Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. J. Clin. Invest. 90: 174-179.
Dunn, J.S., Sheehan, H.L. and McLethie, N.G. (1943). Necrosis of islets of Langerhans produced experimentally. Lancet 1:
484-487.
Gruppuso, P.A., Boylan, J.M., Posner, B.I., Faure, R. and Brautigan, D.L. (1990). Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin receptor and epidermal growth factor receptors in normal and alloxan diabetic rats. J. Clin. Invest. 85: 1754-1760.
Heikkila, R.E., Winston, B., Cohen, G. and Barden, H. (1976). Alloxan induced diabetes, evidence for hydroxyl radicals as a cytotoxic intermediate. Biochem Pharmacol 25: 1085-1092.
Jain, S.K. (1968). Medicinal Plants. National Book Trust, India. pp 1-216.
Jendrassik , L. and Gróf , P. (1938). Vereinfachte photometrische Methoden zur Bestimmung des Blutbilirubins. Biochem Zeitschrift. 297:82-9.
Katsumata, K., Katsumata, K. Jr. and Katsumata, Y. (1992). Protective effect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats. Horm Metab Res 24:508-510.
Kliber, A., Szkudelski, T. and Chichlowska, J. (1996). Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas. J Physiol Pharmacol 47: 321-328.
Latha, M. and Pari, L (2004). Effect of an Aqueous extract of scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes. Braz. J. Med. Biol. Res. Volume 37 (4): 577-586.
Lenzen, S. and Panten, U. (1988). Alloxan history and mechanism of action. Diabetologia 31: 337-342.
Nelson, L.D. and Cox, M.M. (2006). Hormonal Regulation and Integration of Mammalian Metabolism.In: Lehninger Principles of Biochemistry. 4th edition. W.H. Freeman and Company. Pp 881-910.
Newall C. A., Anderson L. A. and Phillipson J. D. (1996). Herbal Medicines: A Guide for Health-Care Professionals. London, England: The Pharmaceutical Press:101-103.
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