Histopathological Assessment of the Kidney of STZ Induced Diabetic Rats Treated with Macerated Costus Spicatus Jacq. Rhizome Extract
Keywords:
Kidney tissues, Tubular necrosis, Glomerular damages, Diabetic mellitus, Costus spicatusAbstract
Diabetes mellitus is a serious chronic metabolic disorder. Effective control of the blood glucose level is required in preventing or reversing diabetic complications and improving the quality of life in both types 1 and 2 diabetic patients. This study was undertaken to assess the nephro-protective and possible reversible effect of Costus spicatus rhizomes extract on cyto-architectural alterations observed following administration of STZ (150mg/kg) which was maintained over a given period of time. Normal control (NC) animals kidney tissues is stable, while diabetic control group showed high level cellular abnormalities including tubular necrosis, thickening of basement membrane, glomerular damages and edematous convulated tubules, atrophy and disarrangement of cytoartitectural component. The administration of macerated preparation of Costus spicatus (rhizomes extract) to diabetic rats restored the changes in the architecture of kidney tissues to near normal level.
Downloads
References
King ML, Bidwell D, Shikh A, Voller A, Banatvala JE Coxsackie – B- virus – specific 1gm responses in children with insulin-dependent (Juvenile-onset type 1) diabetes mellitus. Lancet. (1983;i: 1397-99.
Gilman G, Goodman LS. The pharmacological basis of therapeutics.5th ed. New York: Macmillan; 1985.
Momin A. Role of indigenous medicine in primary health care. NewDelhi: First International Seminar on Unani Medicine; 1987, p.54.
Stenman PHS, Groop K, Laakkonen E, Wahlin-Boll E, MelanderA. Relationship between sulfonylurea dose and metabolic effect. Diabet. 1990; 39: 108A.
Stone JR, Bruneval P, Angelini A, Bartoloni G, Basso C, Batoroeva L, et al. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatorydiseases. Cardiovasc Pathol 2015.
Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Consensus statement on surgical pathology of the aorta from the Society for CardiovascularPathology and the Association for European Cardiovascular Pathology: II. Noninflammatory degenerative diseases — nomenclature and diagnostic criteria.Cardiovasc Pathol 2016; 25:247–57.
Keith G, Tolman MD, Fonseca AV, Meng H, Tan and Dalpiaz A. Narrative Review.Hepatobiliary disease in type 2 diabetes mellitus.Annals of Internal Medicine, 2004 ;141: 946 - 956.
Lopez- Candales AMetabolic syndrome X:a comprehensive review of the pathophysiology and recom-mended therapy.J.Med. 2001; 32: 283-300.
Tjalve H. Streptozotocin: distribution, metabolism andmechanisms of action, Uppsala, J Med Sci., Suppl 1983; 39: 145-157.
Szkudelski T Streptozotocin nicotinamide induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med. (Maywood) 2012; 237: 481-490.
IDF, Internacional Diabetes Federation – IDF Diabetes Atlas - 4th Edition, 2009.
Abraira C, Colwell JA, Nuttall FQ, Sawin CT, Nagel NJ, Comstock JP. VeteransAffairs Cooperative Study on glycemic control and complications in type II dia-betes (VA CSDM). Results of the feasibility trial. Veterans Affairs CooperativeStudy in Type II Diabetes. Diabetes Care 1995; 18:1113–23.
Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S. Intensive insulintherapy prevents the progression of diabetic microvascular complications inJapanese patients with non-insulindependent diabetes mellitus: a randomizedprospective 6-year study. Diabetes Res Clin Pract., 1995; 28:103–17.
DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 1999; 131:281–303.
Mathew, P.T and K.T. Augusti,. Hypoglycaemic effects of onion, Allium cepa linn on diabetes mellitus-a preliminary report. Indian J. Physiol. Pharmacol., 1975; 19: 213-217.
M.A. Jayasri A, Radha TL, Mathew. Amylase and a-glucosidase inhibitoryactivity of Costus pictus D Don in the management of diabetes, J. Herb. Med.Toxicol. 2009; 3: 91–94.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
