FORMULATION AND EVALUATION OF ATENOLOL PULSATILE PRESS COATED TABLETS USING RUPTURABLE AND ERODIBLE POLYMERS
Keywords:
Pulsatile system, Press coating, Rupturable polymer, Erodible polymer, HypertensionAbstract
Pulsatile systems are best for the drugs, which follows chronopharmacological behaviour where night time dosing is required, drugs having high first-pass effect and having specific site of absorption in GIT. In this study, colon targeted pulsatile release tablets of atenolol was prepared using press coating technique to treat hypertension in the early hours of the morning. Pulsatile release of atenlol was achieved by press coating of atenolol core tablet using combination of rupturable and erodible polymers. Mixtures different weight ratio of HPMC K4M and EC (150:00, 125:25, 100:50, 75:75, 50:100, 25:125, 00:150) were press coated over atenolol core tablets to release atenolol after a desired lag time of about 6– 6.5 hr. Formulations HE4 (75:75) and HE5 (50:100) compression coated tablets achieve a burst release of atenolol after 6.5 hr and 6 hr lag time respectively, which is applicable pulsatile drug delivery of atenolol for hypertension.
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