In vivo Evaluation of Antiproliferative Activity of a Novel Benzimidazole De-rivative Against Daltons Lymphoma Ascitic in Swiss Albino Mice
Keywords:
Antiproliferative activity, Benzimidazole, DAL, Haematological parametersAbstract
The present work was to evaluate the antiproliferative activity of a novel benzimidazole derivative, [N-[3-chloro-2-oxo-4-(2-hydroxyphenyl)-4-oxoazetidin-1yl]-2-(2-methyl-1H-benzimidazol-1-yl)acetamide] against tumour induced in female Swiss albino mice. The effective dose of the test compound was determined as 10 mg/kg body weight. Two doses of the test compound were used for the evaluation. 5- Fluorouracil at a dose of 20 mg/kg body weight was used as the standard. Derived, haemotological and biochemical parameters were evaluated. RBC, Hb level, platelet count and packed cell volume that reduced significantly in cancer control group became normal after treatment with test drug. WBC count that increased significantly in DAL control group became normal by treatment with test drug. The results strongly support the antiproliferative activity of novel benzimidazole derivative [N-[3-chloro-2-oxo-4-(2-hydroxyphenyl)-4-oxoazetidin-1yl]-2-(2-methyl-1H-benzimidazol-1-yl)acetamide] against cancer induced female Swiss albino mice.
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