Preparation and evaluation of multipurpose medicated chocolate
DOI:
https://doi.org/10.47957/ijpda.v12i4.602Keywords:
Medicated chocolate, anti-diabetic, anti-inflammatory, anti-oxidantsAbstract
Purpose: The primary objective of current study was to create a chocolate formulation incorporating medicinal herbal ingredients for multiple uses. Method: The method include extraction of herbal material and mixing to prepare syrup to formulate chocolate.
Result: Viscosity Determination of Chocolate Base: It is determined by Brookfield viscometer and observed to be 560cp viscosity = 0.40kg/ms. The amount of force needed to break the tablet may be found using a Monsanto Hardness Tester or a Pfizer Hardness Tester and is found to be 0.2 Kg/cm² . No Flat or Sugar Bloom observed. The formulation is stabal at 2-80C.
Conclusion: According to the results, the chocolate made the mixture feel velvety smooth. Additionally, it effectively disguised the medicine's bad taste, giving it a more appealing choice for consumption. In addition, the medicated chocolate demonstrated therapeutic effectiveness and showed potential as an oral drug delivery mechanism. It shows antitussive, anti-diabetic, anti-inflammatory, and antiviral properties and hence used as multipurpose chocolate.
Downloads
References
Afoakwa E. 2010. Chocolate science and technology. Wiley-Blackwell Publication.
Philip KW. 2015. Chocolate in Science, Nutrition and Therapy: An Historical Perspective, in Chocolate and Health: Chemistry, Nutrition and Therapy. )
Devare RR, Chaudhari AS, Dewang SP, Patil B.V, Patil MA, Pawar PS. Chocolate Formulation as Drug Delivery System for Paediatrics. Indian Journal of Drugs, 7(4), 133- 139 (2019)
Kolekar SY, Mulani AS, Tamboli AF, More NH and Misal AA. Formulation and Evaluation of Paediatric Herbal Chocolate. European Journal of Biomedical and Pharmaceutical sciences, 8(6), 458-462(2021)].
Sunil R, Mounika K, Shalini S, Venkatesham A. Design and fabrication of medicated chocolate formulation by chocolate drug delivery system. Journal of Current Pharma Research, 2016; 7(1): 2010-20.)
Knight Ian. 1999. Chocolate and Cocoa: Health and Nutrition. Blackwell Publication.)
Narayan D. 2015. Therapeutic Benefits of Chocolate. [ONLINE] Available at: http://www.biotecharticles.com/Healthcare-Article/Therapeutic-Benefits-of-Chocolate-3155.html.[Accessed on 15 June 2015].
Davide G, Cristina L, Stefano N, Giovambattista D, Claudio F. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressurein healthy persons. American J Clinical Nutrition, 2005; 81(3):611-614.
James F, Gerd P, Albert K. Effect of Chocolate on Acne Vulgaris. The Journal of the American Medical Association, 1969; 210(11): 2071-2074.
Geleijnse J. Tea flavonoids may protect against atherosclerosis: the Rotterdam study. Archives Internal Medicine, 1999; 159: 2170– 2174.
Ying W, Joe V, Terry E, John P, Sheryl L, Penny K. Etherton Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. American J clinical nutrition, 2001; 74(5):596-602.
Rodgers C. The role of aversive bittering agents in the prevention of pediatric poisonings. Pediatrics, 1994; 93: 68-69.
Liem G, Mennella A. Sweet and sour preferences during childhood: role of early experiences. Developmental Psychobiology, 2002; 41(4): 388-395.
Lang KW. Delivery of active agents using a chocolate vehicle. US Patent; 2007; 0269558.
Rosa M, Cristina A. More antioxidants in cocoa. J Nutrition, 2001; 131(3):834.)
Haritha K, Kalyani L, Lakshmana RA. Health Benefits of Dark Chocolate Journal of Advanced Drug Delivery, 1(4), 184-195, (2014)
Rajesh. H, Rao S. N, Prathima. K. Shetty, Megha Rani. N, Rejeesh E.P, Lovelyn Joseph. Phytochemical analysis of aqueous extract of ocimum sanctum linn. International Journal of Universal Pharmacy and Bio Sciences, 2013; 2(2):462-468
Firoj A. Tamboli, Harinath N. More. Evaluation of Anti ulcer and Antioxidant activity of Barleria gibsoni Dalz. Leaves. Pharmcognosy Research, 2016; 8(4): 226-230.
Tamboli F, Rangari V, Killedar S, Jadhav S, Ghatage T, Kore V. Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.). Marmara Pharm J, 2018; 22(1): 66-73)
Lopez FL, Ernest TB, Tuleu C, Gul MO. Formulation approaches to paediatric oral drug delivery: benefits and limitations of current platforms. Archives of Applied Science Research, 12(11),1727-40 (2015)].
Nugent AP. Health properties of resistant starch. Nutrition Bulletin, 30, 27-54 (2005)].
Champ MMJ. Physiological aspects of resistant starch and in vivo measurements. Int. J. Res. Pharma. Biomedical Sci., 87(3),749-755(2004)].
Sharma M, Jain DK. Chocolate formulation as drug delivery system for pediatrics. Indonesian J Pharmacy, 2012; 23(4): 216-224.)
Meng CC, Jalil AM, Ismail A. Phenolic and theobromine contents of commercial dark, milk and white chocolates on the Malaysian market. Molecules, 14, 200–209, (2009)
Viswanath V, Narasimha R B, Purushothaman M, Sireesha S. Formulation and evaluation of fexofenadine hydrochloride and paracetamol chocolate for paediatrics. World Journal of Pharmaceutical Research,4(9), 842-858, (2015)].
Pawar PG, Darekar AB, Saudagar RB. Medicated chocolate and lollipop: a novel drug delivery system for pediatric patient. International Journal of Pharmaceutical Sciences, 9(1): 677-6969(2018)
IPC, (2007) Indian Pharmacopoeia 2007 Voume 3, The Indian Phamacopoeia Commission: Ghaziabad )
Reddy S, Mounika K, Venkatesham A. Design and fabrication of medicated chocolate formulation by
chocolate DDS. International Journal of Current Pharmaceutical Research, 9(5), 128-133(2017)
Sharma M, Jain DK. Chocolate formulation as drug delivery system for pediatrics. Indonesian J Pharmacy, 2012; 23(4): 216-224.
Mokate R, Kharad D, Badadhe S, Purnale V, Sakhare N, Pawar T, An overview of prepapation and evaluation of Polyherbal mouthwash.Sys. review in pharmacy, 2023; 578-582.
Published
How to Cite
Issue
Section
Copyright (c) 2025 Rajesh Mokate, Jayashree Kokat, Aher Puja Garje Aarti, Badadhe Sandip, Aher Puja Garje Aarti, Agarkar Prerana
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
