Pharmacopoeial standardization and quality evaluation of saathiladhi chooranam: a classical siddha polyherbal formulation

Abstract

Saathiladhi Chooranam is a classical Siddha formulation traditionally prescribed for the management of stomach ulcers and other gastrointestinal ailments. The present study was undertaken to establish comprehensive standardization parameters for this formulation in accordance with AYUSH and WHO guidelines, ensuring its quality, safety, and therapeutic reliability. Physicochemical, phytochemical, chromatographic, microbial, heavy metal, and aflatoxin analyses were performed. The drug displayed characteristic physicochemical properties and a distinct HPTLC fingerprint, which can serve as a reference for identity and quality assurance in future studies. Phytochemical screening revealed the presence of bioactive compounds including carbohydrates, glycosides, phenolic compounds, and tannins, which may contribute to its gastroprotective properties. Heavy metal analysis confirmed all values to be within WHO permissible limits, while aflatoxin content was also within safe limits, ensuring toxicological safety. Microbial analysis indicated overall compliance with WHO standards. The findings provide a comprehensive profile for Saathiladhi Chooranam, contributing valuable reference data for regulatory purposes and supporting its continued safe use as a therapeutic option for stomach ulcers in Siddha medicine.