Enhancing prodrug development, strategies and challenges

Abstract

To enhance their pharmacokinetic and pharmacodynamic characteristics, prodrugs are bio reversible derivatives of active medicinal ingredients. Prodrug creation, despite its potential, is a complicated process that involves factors like membrane permeability, enzymatic activation, and chemical stability. Different prodrug development approaches, such as mutual prodrugs, bio precursor prodrugs, and carrier-linked prodrugs, are covered in this review. We also draw attention to the difficulties in prodrug development, including addressing formulation problems, guaranteeing safety and efficacy, and forecasting metabolic destiny. Through comprehension of these tactics and obstacles, scientists can create more potent prodrugs that improve the therapeutic effectiveness and safety of medications. A viable approach to overcoming the drawbacks of drug delivery, such as low bioavailability, toxicity, and lack of selectivity, is prodrug creation. Researchers can enhance the pharmacokinetic and pharmacodynamic characteristics of medicinal medicines by creating prodrugs that can be activated in vivo. Recent developments in prodrug development, such as creative activation mechanisms, targeted delivery methods, and revolutionary prodrug design tactics, are highlighted in this abstract. We'll talk about the prospects and difficulties in prodrug development, with an emphasis on how prodrugs could improve the safety and effectiveness of a variety of medicinal medicines.