PHARMACODYNAMIC EVALUATION OF USHNAVAAYUMENICHOORANAM IN A CARRAGEENAN-INDUCED PAW EDEMA MODEL IN WISTAR RATS

Saranya R; Chitra Uq; Sudhamathi Pushparaj

Authors

R.Saranya PG scholar, Department of Pothumaruthuvam, Government Siddha Medical College, Chennai.
U.Chitra Lecturer, Department of Pothumaruthuvam, Government Siddha Medical College, Chennai.
Sudhamathi Pushparaj Professor, Department of Pothumaruthuvam, Government Siddha Medical College, Chennai.

Keywords:

UshnaVaayuMeniChooranam, anti-inflammatory activity, in vivo study, carrageenan-induced paw edema, Siddha medicine

Abstract

Background: Phytochemicals derived from medicinal plants continue to play a vital role in the development of anti-inflammatory drugs. UshnaVaayuMeniChooranam (UVMC), a traditional Siddha polyherbal formulation, is commonly used for the treatment of inflammatory disorders. However, there is limited scientific evidence supporting its anti-inflammatory efficacy. The present study aimed to evaluate the in vivo anti-inflammatory activity of UVMC in Wistar rats using the carrageenan-induced paw edema model.

Materials and Methods: Acute inflammation was induced by a subplantar injection of 1% carrageenan. The animals were divided into four groups (n = 6): disease control, indomethacin (10 mg/kg), UVMC (200 mg/kg), and UVMC (400 mg/kg). The percentage inhibition of paw edema was calculated. Histopathological examination of paw tissues and analysis of hematological parameters were also performed.

Results: UVMC produced a significant and dose-dependent reduction in paw edema compared to the disease control group (P < 0.05–0.001). At the fifth hour, the percentage inhibition was 25.18% (200 mg/kg) and 40.62% (400 mg/kg), which was comparable to indomethacin (36.74%). Histopathological findings revealed reduced inflammatory cell infiltration and restoration of normal tissue architecture, particularly in the high-dose group.

Conclusion: The findings demonstrate that UVMC possesses significant anti-inflammatory activity in an acute experimental model, thereby supporting its traditional use in Siddha medicine.

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